![]() Cell signaling is a vital communication mechanism that governs the activities of a cell and it is errors in these pathways that are responsible for a variety of diseases, such as autoimmunity and cancer. Able to regulate the amplitude, speed, sensitivity and specificity of signal transduction, scaffold proteins can allow engineering of new protein signaling pathway behaviors by mediating pathway regulation and feedback 1. 14-3-3 scaffold proteins are part of a family of natural dimeric proteins, which are found commonly in humans and eukaryotes. This research is a focus point for the group, which is collectively working to gain a better understanding of protein-protein interactions and how they can be harnessed for therapeutic or diagnostic purposes, Anniek explained. SelectScience ® spoke to Anniek to discover how these scaffold proteins can be used for therapeutic applications and to learn about the technology enabling her research. Here, Anniek den Hamer, graduate student of Professor Luc Brunsveld, Faculty of Biomedical Engineering and part of the chemical biology group, is attempting to engineer small synthetic signaling networks using 14-3-3 scaffold proteins as a small molecule-controlled binding platform. The Eindhoven University of Technology is the stage for a host of groundbreaking research into synthetic biology and the use of scaffold proteins in protein signaling networks. you can perform measurements in one hour compared to other assays that can take one day, so that’s a big difference.
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